One thing that I don't see enough of in job ads in my opinion is requests for developers with specific domain experience. Quite often I just see generic "junior/senior C# developer with ASP .NET" postings and then when you dig into who the hiring company is they are in a very specific industry like insurance or health care.
Industry specific domains can gain a lot by hiring developers that already have work experience in them. For one, they're already familiar with the terminology they need to effectively communicate with end users. In addition, in a world where developers have a lot of complaints about the lack of quality of specifications they get for projects, by having domain knowledge they can better assist the principals (end users) in crafting better specifications and being able to sniff out flaws in the specification instead of just blindly following it.
Finally, if your principals know that you have an understanding of their part of the business and make an effort to understand the facets of their jobs, it builds a trust relationship that is incredibly valuable over the course of your employment.
I'm not advocating not hiring a talented developer because they don't have domain experience in your niche, but if I get two resumes of relatively equal development skill but one has domain experience, I'm calling that person first!