We all run IISLockdown on our computers, because we are security-conscious developers, right?
If you have and you are having any sort of IIS problems, make sure to check the URLScan logs. You can find them at %WINDOWS%\system32\inetsrv\urlscan. If any requests are being rejected due to URLScan filters, the log file will show the reason why a request was rejected.
I spent half-an-hour trying to figure out why the computer couldn’t find my BizTalkServerRepository. Aaargh!